A multi-inversion-recovery magnetic resonance fingerprinting for multi-compartment water mapping

This study aimed at introducing short-T1/T2 compartment to MR fingerprinting (MRF) 3 T. Water that is bound myelin macromolecules have significantly shorter T1 and T2 than free water can be distinguished from by multi-compartment analysis. We developed a new multi-inversion-recovery (mIR) mapping-MRF based on an unbalanced steady-state coherent sequence (FISP). mIR pulses with interval of 400 or 500 repetition times (TRs) were inserted into the conventional FISP MRF sequence. Data our proposed was used quantify different compartments, including water, gray matter white brain virtue iterative non-negative least square (NNLS) reweighting. Three healthy volunteers scanned clinical T MRI. Using extended phase graph simulation, we found scheme four IR allowed differentiation between short long T1/T2 components. For in vivo experiments, achieved quantification image resolution 1.17 × 5 mm /pixel. As compared technique single IR, improved detection content. In addition, using spiral-in/out trajectory provided higher signal level spiral-out trajectory. Myelin 4 qualitatively similar. Meanwhile, showed fewer artifacts detection. for rapid compartments.